Pub. Date : 2005 Jan
PMID : 15619225
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice. | Acetaminophen | lipopolysaccharide binding protein | Mus musculus |
| 2 | We found that LBP KO mice were protected from acetaminophen-induced hepatotoxicity. | Acetaminophen | lipopolysaccharide binding protein | Mus musculus |
| 3 | At 350 mg/kg of acetaminophen, LBP KO mice had significantly less liver injury and necrosis than wild-type mice. | Acetaminophen | lipopolysaccharide binding protein | Mus musculus |
| 4 | Repletion studies in LBP KO mice using an LBP-adenoviral construct resulted in significantly more hepatic injury and necrosis after acetaminophen exposure compared with mice receiving the control adenoviral construct. | Acetaminophen | lipopolysaccharide binding protein | Mus musculus |
| 5 | Repletion studies in LBP KO mice using an LBP-adenoviral construct resulted in significantly more hepatic injury and necrosis after acetaminophen exposure compared with mice receiving the control adenoviral construct. | Acetaminophen | lipopolysaccharide binding protein | Mus musculus |
| 6 | In conclusion, LBP KO mice are protected from toxicity with a decrease in hepatic necrosis following acetaminophen challenge. | Acetaminophen | lipopolysaccharide binding protein | Mus musculus |
| 7 | This suggests a novel role for LBP in modulating acetaminophen-induced liver injury. | Acetaminophen | lipopolysaccharide binding protein | Mus musculus |