Title : Selective antagonism of GABAA receptor subtypes: an in vivo approach to exploring the therapeutic and side effects of benzodiazepine-type drugs.

Pub. Date : 2005 Jan

PMID : 15618946






2 Functional Relationships(s)
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1 This review discusses the experimental uses of b-carboline-3-carboxylate-t-butyl ester (betaCCT), a drug that binds preferentially to the GABAA alpha1 subtype but exerts no action (ie, is a pharmacologic antagonist at the GABAA alpha1 subtype receptor). tert-butyl beta-carboline-3-carboxylate gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus
2 betaCCT antagonized the ataxic but not muscle relaxant effects of BZs, a finding that implicates the GABAA alpha1 subtype receptor in ataxia but not muscle relaxation. tert-butyl beta-carboline-3-carboxylate gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus