Title : Rat renal organic anion transporter rOAT1 mediates transport of urinary-excreted cephalosporins, but not of biliary-excreted cefoperazone.

Pub. Date : 2002

PMID : 15618660






2 Functional Relationships(s)
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1 The inhibition constants of these cephalosporins to rOAT1-mediated p-aminohippurate (PAH) uptake were 72 microM for cefazolin, 298 microM for cefoperazone, 718 microM for cefotiam and 6 mM for cephalexin. Cefoperazone solute carrier family 22 member 6 Rattus norvegicus
2 Eadie-Hofstee plot analysis revealed that cefoperazone as well as cefotiam inhibited rOAT1-mediated PAH uptake competitively. Cefoperazone solute carrier family 22 member 6 Rattus norvegicus