Title : Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors.

Pub. Date : 2004 Dec 30

PMID : 15615524






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Results obtained demonstrated that most of alkanesulfonamide derivatives displayed a COX-2 preferential inhibition with selectivity ratio values (IC(50)(COX-1)/IC(50)(COX-2)) up to 7.92 (celecoxib displaying a ratio value of 7.46 in the same test). Celecoxib mitochondrially encoded cytochrome c oxidase I Homo sapiens