Title : Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors.

Pub. Date : 2005 Apr

PMID : 15608085






2 Functional Relationships(s)
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1 In mesenteric arteries, constriction to phenylpropanolamine was not affected by the selective alpha2-adrenergic antagonist, rauwolscine (10(-7) M) but was abolished by the selective alpha1-adrenergic antagonist, prazosin (3 x 10(-7) M). Phenylpropanolamine adrenoceptor alpha 1D Homo sapiens
2 At low concentrations, it constricts blood vessels that express functional alpha2-adrenoceptors, whereas at much higher concentrations, phenylpropanolamine also activates vascular alpha1-adrenoceptors. Phenylpropanolamine adrenoceptor alpha 1D Homo sapiens