Title : Glucose inhibits meiotic DNA replication through SCFGrr1p-dependent destruction of Ime2p kinase.

Pub. Date : 2005 Jan

PMID : 15601864






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The effects of glucose on Sic1p levels and DNA replication required Grr1p, a component of the SCF(Grr1p) ubiquitin ligase. Glucose SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C
2 The effects of glucose on Sic1p levels and DNA replication required Grr1p, a component of the SCF(Grr1p) ubiquitin ligase. Glucose SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C
3 Sic1p is negatively regulated by Ime2p kinase, and several observations indicate that glucose inhibits meiotic DNA replication through SCF(Grr1p)-mediated destruction of this kinase. Glucose SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C