Title : Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.

Pub. Date : 2004 Dec

PMID : 15599405






1 Functional Relationships(s)
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1 Activation of invariant CD1d-dependent NK T cells (iNKT cells) in vivo through administration of the glycolipid ligand alpha-galactosylceramide (alpha-GalCer) or the sphingosine-truncated alpha-GalCer analog OCH leads to CD40 signaling as well as the release of soluble molecules including type 1 and gamma interferons that contribute to DC maturation. Sphingosine CD1d molecule Homo sapiens