Title : A 120 kDa nuclear phospholipase Cgamma1 protein fragment is stimulated in vivo by EGF signal phosphorylating nuclear membrane EGFR.

Pub. Date : 2004 Dec 21

PMID : 15595842






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The tyrosine-phosphorylated 120 kDa protein interacts with activated EGFR, binds phosphatidylinositol-3-OH-kinase enhancer (PIKE), enhances nuclear phosphatidylinositol-3-OH-kinase (PI[3]K) activity, and generates diacylglycerol (DAG) in response to the EGF signal to the nucleus in vivo. Diglycerides ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Mus musculus
2 The tyrosine-phosphorylated 120 kDa protein interacts with activated EGFR, binds phosphatidylinositol-3-OH-kinase enhancer (PIKE), enhances nuclear phosphatidylinositol-3-OH-kinase (PI[3]K) activity, and generates diacylglycerol (DAG) in response to the EGF signal to the nucleus in vivo. Diglycerides ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Mus musculus