Pub. Date : 2004 Dec 1
PMID : 15585641
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | This study evaluated the efficacy of mTOR inhibition in the treatment of tamoxifen-resistant breast carcinoma characterized by high Akt activity. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | We found that MCF-7 breast cancer cell lines expressing a constitutively active Akt are able to proliferate under reduced estrogen conditions and are resistant to the growth inhibitory effects of tamoxifen, both in vitro as well as in vivo in xenograft models. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | These data corroborate prior findings indicating that Akt activation induces resistance to tamoxifen in breast cancer cells. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Importantly, these data indicate a novel mechanism for tamoxifen resistance and suggest that blockage of the phosphatidylinositol 3"-kinase/Akt signaling pathway by mTOR inhibition effectively restores the susceptibility of these cells to tamoxifen. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | Importantly, these data indicate a novel mechanism for tamoxifen resistance and suggest that blockage of the phosphatidylinositol 3"-kinase/Akt signaling pathway by mTOR inhibition effectively restores the susceptibility of these cells to tamoxifen. | Tamoxifen | AKT serine/threonine kinase 1 | Homo sapiens |