Pub. Date : 2004 Dec
PMID : 15582497
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to determine whether novel ERalpha-selective agonists, propyl pyrazole triol (PPT) and the tetrahydrochrysene (R,R-THC), up-regulate the expression of vascular endothelial growth factor receptor-2 (VEGFR-2), and promote VEGF-stimulated endothelial cell proliferation in primary cultures of adult female microvascular endothelial cells co-expressing endogenous ERalpha and ERbeta. | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol | estrogen receptor 1 | Homo sapiens |
| 2 | The aim of this study was to determine whether novel ERalpha-selective agonists, propyl pyrazole triol (PPT) and the tetrahydrochrysene (R,R-THC), up-regulate the expression of vascular endothelial growth factor receptor-2 (VEGFR-2), and promote VEGF-stimulated endothelial cell proliferation in primary cultures of adult female microvascular endothelial cells co-expressing endogenous ERalpha and ERbeta. | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol | estrogen receptor 1 | Homo sapiens |
| 3 | The aim of this study was to determine whether novel ERalpha-selective agonists, propyl pyrazole triol (PPT) and the tetrahydrochrysene (R,R-THC), up-regulate the expression of vascular endothelial growth factor receptor-2 (VEGFR-2), and promote VEGF-stimulated endothelial cell proliferation in primary cultures of adult female microvascular endothelial cells co-expressing endogenous ERalpha and ERbeta. | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol | estrogen receptor 1 | Homo sapiens |
| 4 | The aim of this study was to determine whether novel ERalpha-selective agonists, propyl pyrazole triol (PPT) and the tetrahydrochrysene (R,R-THC), up-regulate the expression of vascular endothelial growth factor receptor-2 (VEGFR-2), and promote VEGF-stimulated endothelial cell proliferation in primary cultures of adult female microvascular endothelial cells co-expressing endogenous ERalpha and ERbeta. | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol | estrogen receptor 1 | Homo sapiens |
| 5 | PPT- or R,R-THC-stimulated increase in VEGF binding was significantly different between ERalpha+ and ERalpha- microvascular endothelial cell samples (P < .001 and P < .05, respectively). | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol | estrogen receptor 1 | Homo sapiens |
| 6 | PPT- or R,R-THC-stimulated increase in VEGF binding was significantly different between ERalpha+ and ERalpha- microvascular endothelial cell samples (P < .001 and P < .05, respectively). | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol | estrogen receptor 1 | Homo sapiens |
| 7 | PPT, R,R-THC, and 17beta-estradiol significantly augmented VEGF-stimulated microvascular endothelial cell proliferation in ERalpha+ (P < .05), but not in ERalpha- samples. | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol | estrogen receptor 1 | Homo sapiens |