Title : Reversible oxidation of ERK-directed protein phosphatases drives oxidative toxicity in neurons.

Pub. Date : 2005 Feb 18

PMID : 15579467






1 Functional Relationships(s)
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1 In this study, we demonstrate that during oxidative stress, ERK-directed phosphatases of both the serine/threonine- and tyrosine-directed classes are selectively and reversibly inhibited via a mechanism that is dependent upon the oxidation of cysteine thiols. Tyrosine mitogen-activated protein kinase 1 Mus musculus