Title : Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells.

Pub. Date : 2005 Feb

PMID : 15572421






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5"-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells. cdb caspase 3 Homo sapiens
2 Western blot analysis revealed that treatment with CDB-2914 significantly decreased the expression of PCNA and Bcl-2 protein and increased the expression of cleaved caspase-3 and cleaved PARP in a dose-dependent manner compared with untreated control cultures. cdb caspase 3 Homo sapiens