Pub. Date : 2004 Dec 14
PMID : 15548613
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The structure of carbonmonoxy neuroglobin reveals a heme-sliding mechanism for control of ligand affinity. | Heme | neuroglobin | Mus musculus |
| 2 | Unlike in Mb, in Ngb the sixth coordination position of the heme iron is occupied by the distal histidine, in the absence of an exogenous ligand. | Heme | neuroglobin | Mus musculus |
| 3 | The heme relocation is accompanied by a significant decrease of structural disorder, especially of the EF loop, which may be the signal whereby Ngb communicates hypoxic conditions. | Heme | neuroglobin | Mus musculus |
| 4 | This unexpected structural change unveils a heme-sliding mechanism of affinity control that may be of significance to understanding Ngb"s role in the pathophysiology of the brain. | Heme | neuroglobin | Mus musculus |