Title : Polymerization of the triphosphates of AraC, 2',2'-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase.

Pub. Date : 2004 Dec 15

PMID : 15548380






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We examined how the triphosphates of OSI-7836 (T-araCTP), cytarabine (araCTP), and gemcitabine (dFdCTP) affected the initiation of new DNA strands by the pol alpha primase complex. Arabinofuranosylcytosine Triphosphate DNA polymerase alpha 1, catalytic subunit Homo sapiens
2 dFdCTP, araCTP, and T-araCTP inhibited pol alpha competitively with respect to dCTP. Arabinofuranosylcytosine Triphosphate DNA polymerase alpha 1, catalytic subunit Homo sapiens
3 Furthermore, pol alpha polymerized T-araCTP only nine-fold less well than dCTP, whereas it polymerized araCTP and dFdCTP 24- and 83-fold less well, respectively. Arabinofuranosylcytosine Triphosphate DNA polymerase alpha 1, catalytic subunit Homo sapiens