Title : Activation of proinflammatory caspases by cathepsin B in focal cerebral ischemia.

Pub. Date : 2004 Nov

PMID : 15545923






2 Functional Relationships(s)
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1 The apical position of cathepsin B in both caspase-activation cascades was confirmed by pretreatment of the animals with the cathepsin B inhibitor CA-074, which also potently protected cortical structures from ischemic damage, indicating involvement of the proteases in the lesion process. N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline cathepsin B Mus musculus
2 The apical position of cathepsin B in both caspase-activation cascades was confirmed by pretreatment of the animals with the cathepsin B inhibitor CA-074, which also potently protected cortical structures from ischemic damage, indicating involvement of the proteases in the lesion process. N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline cathepsin B Mus musculus