Pub. Date : 2004 Nov
PMID : 15539083
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1: role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein. | Imatinib Mesylate | protein tyrosine phosphatase, non-receptor type 2 | Mus musculus |
| 2 | Importantly, reconstitution of TC-PTP in KTR cells to levels found in parental KT-1 cells restored their sensitivity to imatinib mesylate as monitored by reduced proliferation and increased apoptosis. | Imatinib Mesylate | protein tyrosine phosphatase, non-receptor type 2 | Mus musculus |
| 3 | CONCLUSIONS: We have demonstrated that forced expression of TC-PTP in imatinib mesylate-resistant KTR cells can restore sensitivity to imatinib mesylate. | Imatinib Mesylate | protein tyrosine phosphatase, non-receptor type 2 | Mus musculus |
| 4 | CONCLUSIONS: We have demonstrated that forced expression of TC-PTP in imatinib mesylate-resistant KTR cells can restore sensitivity to imatinib mesylate. | Imatinib Mesylate | protein tyrosine phosphatase, non-receptor type 2 | Mus musculus |
| 5 | Our studies indicate that loss of TC-PTP may represent a novel mechanism by which CML cells can acquire imatinib mesylate-resistance. | Imatinib Mesylate | protein tyrosine phosphatase, non-receptor type 2 | Mus musculus |