Pub. Date : 2005 Feb
PMID : 15528319
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metabolism of nicotine and cotinine by human cytochrome P450 2A13. | Nicotine | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |
| 2 | Recently, we have demonstrated that heterologously expressed human CYP2A13 is highly active in the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a nicotine-derived carcinogen. | Nicotine | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |
| 3 | In the present study, CYP2A13-catalyzed NNK metabolism was found to be inhibited competitively by nicotine and N"-nitrosonornicotine (NNN), suggesting that both nicotine and NNN are also substrates of CYP2A13. | Nicotine | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |
| 4 | In the present study, CYP2A13-catalyzed NNK metabolism was found to be inhibited competitively by nicotine and N"-nitrosonornicotine (NNN), suggesting that both nicotine and NNN are also substrates of CYP2A13. | Nicotine | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |
| 5 | In the present study, CYP2A13-catalyzed NNK metabolism was found to be inhibited competitively by nicotine and N"-nitrosonornicotine (NNN), suggesting that both nicotine and NNN are also substrates of CYP2A13. | Nicotine | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |
| 6 | In the present study, CYP2A13-catalyzed NNK metabolism was found to be inhibited competitively by nicotine and N"-nitrosonornicotine (NNN), suggesting that both nicotine and NNN are also substrates of CYP2A13. | Nicotine | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |
| 7 | We have further demonstrated that human CYP2A13 is indeed an efficient enzyme in catalyzing C-oxidation of nicotine to form cotinine, with the apparent K(m) and V(max) values of 20.2 microM and 8.7 pmol/min/pmol, respectively. | Nicotine | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |
| 8 | The importance of CYP2A13-catalyzed nicotine and cotinine metabolism in vivo remains to be determined. | Nicotine | cytochrome P450 family 2 subfamily A member 13 | Homo sapiens |