Pub. Date : 2004 Nov
PMID : 15509798
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These effects are likely due to a direct effect of NAD(+) on p53, as a molecule structurally related to part of NAD(+), TDP, also inhibits p53 DNA binding, and the TDP precursor, thiamine (vitamin B(1)), inhibits intracellular p53 activity. | Thiamine | tumor protein p53 | Homo sapiens |
| 2 | These effects are likely due to a direct effect of NAD(+) on p53, as a molecule structurally related to part of NAD(+), TDP, also inhibits p53 DNA binding, and the TDP precursor, thiamine (vitamin B(1)), inhibits intracellular p53 activity. | Thiamine | tumor protein p53 | Homo sapiens |
| 3 | Niacinamide and thiamine affect two p53-regulated cellular responses to ionizing radiation: rereplication and apoptosis. | Thiamine | tumor protein p53 | Homo sapiens |
| 4 | Thus, niacinamide and thiamine form a novel basis for the development of small molecules that affect p53 function in vivo, and these results suggest that changes in cellular energy metabolism may regulate p53. | Thiamine | tumor protein p53 | Homo sapiens |