Pub. Date : 2004 Nov
PMID : 15509798
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NAD+ modulates p53 DNA binding specificity and function. | NAD | tumor protein p53 | Homo sapiens |
| 2 | Small-molecule manipulation of p53 DNA binding activity has been an elusive goal, but here we show that NAD(+) binds to p53 tetramers, induces a conformational change, and modulates p53 DNA binding specificity in vitro. | NAD | tumor protein p53 | Homo sapiens |
| 3 | Small-molecule manipulation of p53 DNA binding activity has been an elusive goal, but here we show that NAD(+) binds to p53 tetramers, induces a conformational change, and modulates p53 DNA binding specificity in vitro. | NAD | tumor protein p53 | Homo sapiens |
| 4 | Small-molecule manipulation of p53 DNA binding activity has been an elusive goal, but here we show that NAD(+) binds to p53 tetramers, induces a conformational change, and modulates p53 DNA binding specificity in vitro. | NAD | tumor protein p53 | Homo sapiens |
| 5 | These effects are likely due to a direct effect of NAD(+) on p53, as a molecule structurally related to part of NAD(+), TDP, also inhibits p53 DNA binding, and the TDP precursor, thiamine (vitamin B(1)), inhibits intracellular p53 activity. | NAD | tumor protein p53 | Homo sapiens |
| 6 | These effects are likely due to a direct effect of NAD(+) on p53, as a molecule structurally related to part of NAD(+), TDP, also inhibits p53 DNA binding, and the TDP precursor, thiamine (vitamin B(1)), inhibits intracellular p53 activity. | NAD | tumor protein p53 | Homo sapiens |
| 7 | These effects are likely due to a direct effect of NAD(+) on p53, as a molecule structurally related to part of NAD(+), TDP, also inhibits p53 DNA binding, and the TDP precursor, thiamine (vitamin B(1)), inhibits intracellular p53 activity. | NAD | tumor protein p53 | Homo sapiens |
| 8 | These effects are likely due to a direct effect of NAD(+) on p53, as a molecule structurally related to part of NAD(+), TDP, also inhibits p53 DNA binding, and the TDP precursor, thiamine (vitamin B(1)), inhibits intracellular p53 activity. | NAD | tumor protein p53 | Homo sapiens |
| 9 | These effects are likely due to a direct effect of NAD(+) on p53, as a molecule structurally related to part of NAD(+), TDP, also inhibits p53 DNA binding, and the TDP precursor, thiamine (vitamin B(1)), inhibits intracellular p53 activity. | NAD | tumor protein p53 | Homo sapiens |
| 10 | These effects are likely due to a direct effect of NAD(+) on p53, as a molecule structurally related to part of NAD(+), TDP, also inhibits p53 DNA binding, and the TDP precursor, thiamine (vitamin B(1)), inhibits intracellular p53 activity. | NAD | tumor protein p53 | Homo sapiens |