Title : Design and synthesis of acyclic triaryl (Z)-olefins: a novel class of cyclooxygenase-2 (COX-2) inhibitors.

Pub. Date : 2004 Nov 15

PMID : 15498669






1 Functional Relationships(s)
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Protein Name
Organism
1 The p-OAc substituent on the C-1 phenyl ring is oriented in a hydrophobic pocket comprised of Met(522), Gly(526), Trp(387), Tyr(348), and Tyr(385), and the C-2 ethyl substituent is oriented towards the mouth of the COX-2 channel in the vicinity of amino acid residues Arg(120), Leu(531), and Val(349). Glycine heterogeneous nuclear ribonucleoprotein C Homo sapiens