Title : Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae.

Pub. Date : 2004 Oct 22

PMID : 15494315






3 Functional Relationships(s)
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Protein Name
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1 Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae. Glucose Gpr1p Saccharomyces cerevisiae S288C
2 In the yeast Saccharomyces cerevisiae, rapid activation of the cAMP pathway by glucose and sucrose requires the GPCR Gpr1. Glucose Gpr1p Saccharomyces cerevisiae S288C
3 Our results obtained by cysteine scanning mutagenesis and SCAM (substituted cysteine accessibility method) of residues in TMD VI provide strong evidence that glucose and sucrose directly interact as ligands with Gpr1. Glucose Gpr1p Saccharomyces cerevisiae S288C