Title : Multiple mechanisms are involved in Ah receptor-mediated cell cycle arrest.

Pub. Date : 2005 Jan

PMID : 15492120






4 Functional Relationships(s)
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1 In the present study, experiments in rat hepatoma cells using dominant-negative DNA-binding-defective AhR and Ah receptor nuclear translocator (Arnt) mutants provided evidence that TCDD-induced AhR-mediated G(1) arrest is only partially regulated by direct AhR transcriptional activity, suggesting that both coactivation and corepression are involved. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor nuclear translocator Rattus norvegicus
2 In the present study, experiments in rat hepatoma cells using dominant-negative DNA-binding-defective AhR and Ah receptor nuclear translocator (Arnt) mutants provided evidence that TCDD-induced AhR-mediated G(1) arrest is only partially regulated by direct AhR transcriptional activity, suggesting that both coactivation and corepression are involved. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor nuclear translocator Rattus norvegicus
3 Studies using a small interfering RNA to down-regulate Arnt protein expression revealed that TCDD-induced G(1) arrest is absolutely dependent on the Arnt protein. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor nuclear translocator Rattus norvegicus
4 Studies using a small interfering RNA to down-regulate Arnt protein expression revealed that TCDD-induced G(1) arrest is absolutely dependent on the Arnt protein. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor nuclear translocator Rattus norvegicus