Title : alpha-MSH and gamma-MSH inhibit IL-1beta induced activation of the hypothalamic-pituitary-adrenal axis through central melanocortin receptors.

Pub. Date : 2004 Nov 15

PMID : 15491790






3 Functional Relationships(s)
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1 The treatment with gamma-MSH (1 microg), an MC3 receptor agonist, resulted in significant reduction of the IL-1beta-induced plasma corticosterone levels. Corticosterone proopiomelanocortin Homo sapiens
2 Besides, treatment with a high dose of alpha-MSH (1 microg) increased plasma corticosterone. Corticosterone proopiomelanocortin Homo sapiens
3 When alpha-MSH was given at a lower dose (0.1 microg), it did not modify corticosterone levels but caused an inhibitory effect on the corticosterone release induced by IL-1beta. Corticosterone proopiomelanocortin Homo sapiens