Title : Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.

Pub. Date : 2004 Oct 21

PMID : 15481991






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Its inhibitory activity against P-gp 170 is approximately 40 times better, based on EC50 (concentration of the compound enhancing 50% of the intracellular vinblastine accumulation in the KB/MDR cells) and 3 times higher, based on Amax (the intracellular vinblastine accumulation of the KB/MDR cells caused by the compound) as compared to baicalein. Vinblastine phosphoglycolate phosphatase Homo sapiens
2 Its inhibitory activity against P-gp 170 is approximately 40 times better, based on EC50 (concentration of the compound enhancing 50% of the intracellular vinblastine accumulation in the KB/MDR cells) and 3 times higher, based on Amax (the intracellular vinblastine accumulation of the KB/MDR cells caused by the compound) as compared to baicalein. Vinblastine phosphoglycolate phosphatase Homo sapiens