Title : Trans-3'-hydroxycotinine O- and N-glucuronidations in human liver microsomes.

Pub. Date : 2005 Jan

PMID : 15470160






2 Functional Relationships(s)
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1 Trans-3"-hydroxycotinine N-glucuronidation in human liver microsomes was significantly correlated with nicotine and cotinine N-glucuronidations, which are catalyzed mainly by UDP-glucuronosyltransferase (UGT)1A4 and was inhibited by imipramine and nicotine, which are substrates of UGT1A4. Nicotine UDP glucuronosyltransferase family 1 member A4 Homo sapiens
2 Trans-3"-hydroxycotinine N-glucuronidation in human liver microsomes was significantly correlated with nicotine and cotinine N-glucuronidations, which are catalyzed mainly by UDP-glucuronosyltransferase (UGT)1A4 and was inhibited by imipramine and nicotine, which are substrates of UGT1A4. Nicotine UDP glucuronosyltransferase family 1 member A4 Homo sapiens