Title : 17alpha-hydroxylase/C17-20 lyase cytochrome P450 mRNA expressions and enzyme activities during the development of arthritis in collagen-induced arthritis mice.

Pub. Date : 2004 Oct

PMID : 15467215






3 Functional Relationships(s)
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1 In our previous study, we have investigated the serum levels of dehydroepiandrosterone (DHEA) in type II collagen (CII)-induced arthritis (CIA) mice. Dehydroepiandrosterone nuclear receptor coactivator 5 Mus musculus
2 In our previous study, we have investigated the serum levels of dehydroepiandrosterone (DHEA) in type II collagen (CII)-induced arthritis (CIA) mice. Dehydroepiandrosterone nuclear receptor coactivator 5 Mus musculus
3 To examine the cause of the retention of DHEA during the development of arthritis in CIA mice in this study, 17alpha-hydroxylase/C17-20 lyase P450 (CYP17) mRNA expressions were measured by real time RT-PCR and the CYP17 enzyme activities were investigated in the liver and testis on days 6, 13, 28 and 48 after CII treatment in DBA/1J mice. Dehydroepiandrosterone nuclear receptor coactivator 5 Mus musculus