Title : Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells.

Pub. Date : 2005 Feb 15

PMID : 15466932






1 Functional Relationships(s)
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1 This is the first report of IDO and TTS regulation by the CTLA-4-B7 system in human CD4(+) and CD8(+) T cells, and raises the possibility that these 2 tryptophan-modulating enzymes provide an important mechanism for regulating immune responses. Tryptophan cytotoxic T-lymphocyte associated protein 4 Homo sapiens