Pub. Date : 2004
PMID : 15466595
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA glycosylase, has recently been shown to excise 5-hydroxyuracil (hoU), 5-hydroxymethyluracil (hmU) and 5-formyluracil (fU) bearing an oxidized group at ring C5 as well as an uracil. | 5-hydroxymethyluracil | single-strand-selective monofunctional uracil-DNA glycosylase 1 | Homo sapiens |
| 2 | Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA glycosylase, has recently been shown to excise 5-hydroxyuracil (hoU), 5-hydroxymethyluracil (hmU) and 5-formyluracil (fU) bearing an oxidized group at ring C5 as well as an uracil. | 5-hydroxymethyluracil | single-strand-selective monofunctional uracil-DNA glycosylase 1 | Homo sapiens |
| 3 | Integration of the present results and the structural data elucidates how hSMUG1 accepts uracil, hoU, hmU and fU as substrates, but not other oxidized pyrimidines such as 5-hydroxycytosine, 5-formylcytosine and thymine glycol, and intact pyrimidines such as thymine and cytosine. | 5-hydroxymethyluracil | single-strand-selective monofunctional uracil-DNA glycosylase 1 | Homo sapiens |