Title : DER7, encoding alpha-glucosidase I is essential for degradation of malfolded glycoproteins of the endoplasmic reticulum.

Pub. Date : 2004 Sep

PMID : 15450188






2 Functional Relationships(s)
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1 We identify DER7 as the gene encoding N-glycan-processing alpha-glucosidase I (EC 3.2.1.106) of the ER and demonstrate that its inactivity, due to a substitution of the conserved glycine residue at position 725 by arginine (G725R) in the der7-1 mutant, leads to ER-stress. n-glycan mannosyl-oligosaccharide glucosidase Saccharomyces cerevisiae S288C
2 We identify DER7 as the gene encoding N-glycan-processing alpha-glucosidase I (EC 3.2.1.106) of the ER and demonstrate that its inactivity, due to a substitution of the conserved glycine residue at position 725 by arginine (G725R) in the der7-1 mutant, leads to ER-stress. n-glycan mannosyl-oligosaccharide glucosidase Saccharomyces cerevisiae S288C