Title : Activation of p21ras by transforming growth factor beta in epithelial cells.

Pub. Date : 1992 Mar 15

PMID : 1544886






2 Functional Relationships(s)
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1 Here we show that both TGF beta 1 and TGF beta 2 (5 ng/ml) result in a rapid (within 6 or 12 min, respectively) stimulation of GTP bound to p21ras in TGF beta-sensitive intestinal epithelial cells. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens
2 Further, the CCL64 epithelial cell line, extremely sensitive to growth inhibition by TGF beta, displayed a concentration-dependent increase in GTP bound to p21ras by TGF beta 1 and a rapid activation of p21ras by TGF beta 2. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens