Title : Amphetamine-evoked gene expression in striatopallidal neurons: regulation by corticostriatal afferents and the ERK/MAPK signaling cascade.

Pub. Date : 2004 Oct

PMID : 15447667






2 Functional Relationships(s)
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1 We report that transection of corticostriatal afferents selectively blocks, whereas enhancement of cortical activity with an ampakine selectively augments, the number of amphetamine-evoked c-fos-positive striatopallidal (but not striatonigral) neurons. Amphetamine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 In addition, blockade of the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling cascade preferentially inhibits the number of amphetamine-evoked c-fos-positive striatopallidal neurons. Amphetamine Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens