Title : Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid.

Pub. Date : 2004 Dec

PMID : 15383625






1 Functional Relationships(s)
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1 Using NAD+, the 3-hydroxymetabolites were efficiently oxidized by homogeneous recombinant AKR1C2 and AKR1C4. NAD aldo-keto reductase family 1 member C4 Homo sapiens