Title : Interleukin-2 promoter activation in T-cells expressing activated Ha-ras.

Pub. Date : 1992 Mar 5

PMID : 1537820






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Its pattern of synergism with a calcium ionophore or the lymphokine interleukin-1 indicates that it replaces a signal mediated by protein kinase C. Interleukin-2 promoter activity in the presence of ras oncoprotein was inhibited by H7, a potent inhibitor of protein kinase C, but not by HA1004, an inhibitor of cyclic nucleotide-dependent kinase, suggesting that protein kinase C mediates the ras effect. Calcium interleukin 2 Homo sapiens