Title : Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis.

Pub. Date : 2004 Oct 15

PMID : 15375007






2 Functional Relationships(s)
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1 Immunoblots, immunohistochemistry, laser-captured microdissection-quantitative reverse-transcription polymerase chain reaction and patch-clamping show that DCA reverses the Kv1.5 downregulation in resistance PAs. Dichloroacetic Acid potassium voltage-gated channel subfamily A member 5 Rattus norvegicus
2 In summary, DCA reverses PA remodeling by increasing the mitochondria-dependent apoptosis/proliferation ratio and upregulating Kv1.5 in the media. Dichloroacetic Acid potassium voltage-gated channel subfamily A member 5 Rattus norvegicus