Pub. Date : 1992 Mar
PMID : 1537311
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have shown previously that GH receptors (GHRs) become phosphorylated on tyrosyl residues when GH-responsive cells are exposed to GH. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 2 | We have shown previously that GH receptors (GHRs) become phosphorylated on tyrosyl residues when GH-responsive cells are exposed to GH. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 3 | In this work we investigate the molecular mechanism by which GH binding stimulates tyrosyl phosphorylation of GHR. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 4 | The rate of in vitro tyrosyl phosphorylation of GH-GHR complexes was not substantially reduced when the GHR preparation was diluted 1:10 or 1:100 before phosphorylation, consistent with a tight association between kinase and substrate (GHR). | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 5 | When cells were labeled metabolically with 35S, and GHRs containing phosphorylated tyrosyl residues were isolated by immunoadsorption to and elution from phosphotyrosyl-binding antibody, the ability to immunoprecipitate 35S-labeled GHR with GHR antibodies was only evident when the cells had been incubated with GH. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 6 | This indicates that in vivo, GHRs are phosphorylated on tyrosyl residues only when GH is bound. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 7 | The increased tyrosyl phosphorylation of GHR detected after incubation of cells with GH is consistent either with GH increasing tyrosine kinase activity associated with the GHR or with GH inducing a conformational change in GHR that renders it susceptible to tyrosyl phosphorylation. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 8 | The increased tyrosyl phosphorylation of GHR detected after incubation of cells with GH is consistent either with GH increasing tyrosine kinase activity associated with the GHR or with GH inducing a conformational change in GHR that renders it susceptible to tyrosyl phosphorylation. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 9 | The increased tyrosyl phosphorylation of GHR detected after incubation of cells with GH is consistent either with GH increasing tyrosine kinase activity associated with the GHR or with GH inducing a conformational change in GHR that renders it susceptible to tyrosyl phosphorylation. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 10 | The increased tyrosyl phosphorylation of GHR detected after incubation of cells with GH is consistent either with GH increasing tyrosine kinase activity associated with the GHR or with GH inducing a conformational change in GHR that renders it susceptible to tyrosyl phosphorylation. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 11 | The increased tyrosyl phosphorylation of GHR detected after incubation of cells with GH is consistent either with GH increasing tyrosine kinase activity associated with the GHR or with GH inducing a conformational change in GHR that renders it susceptible to tyrosyl phosphorylation. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |
| 12 | The increased tyrosyl phosphorylation of GHR detected after incubation of cells with GH is consistent either with GH increasing tyrosine kinase activity associated with the GHR or with GH inducing a conformational change in GHR that renders it susceptible to tyrosyl phosphorylation. | cyclo(tyrosyl-tyrosyl) | growth hormone 1 | Homo sapiens |