Title : Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms.

Pub. Date : 2004 Oct 15

PMID : 15369704






2 Functional Relationships(s)
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1 The mechanisms underlying the PAR-2- and PAR-1-mediated relaxation involved NO, endothelium-derived hyperpolarizing factor (EDHF) and prostanoids, to distinct extent, as evaluated by use of inhibitors of NO synthase, cyclo-oxygenase and Ca2+-activated K+ channels. edhf coagulation factor II (thrombin) receptor Rattus norvegicus
2 These findings demonstrate that endothelial PAR-1 and PAR-2, upon activation, dilate the gastric artery via NO and prostanoid formation and also EDHF mechanisms including gap junctions, which would enhance GMBF. edhf coagulation factor II (thrombin) receptor Rattus norvegicus