Title : Androgen receptor (AR) expression in AR-negative prostate cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic tumors.

Pub. Date : 2004 Nov 1

PMID : 15368471






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 IGF-I significantly enhanced dihydrotestosterone (DHT)-stimulated, but not basal, AR transcriptional activity in PRI cells. Dihydrotestosterone insulin like growth factor 1 Homo sapiens
2 IGF-I significantly enhanced dihydrotestosterone (DHT)-stimulated, but not basal, AR transcriptional activity in PRI cells. Dihydrotestosterone insulin like growth factor 1 Homo sapiens
3 In MET cells, IGF-I significantly suppressed DHT-stimulated transcriptional activity. Dihydrotestosterone insulin like growth factor 1 Homo sapiens
4 In MET cells in which the IGF-IR was re-expressed from a retroviral vector, the effects of DHT and IGF-I on AR activity were similar to those seen in PRI cells. Dihydrotestosterone insulin like growth factor 1 Homo sapiens