Title : Activation of serine/threonine protein phosphatase-1 is required for ceramide-induced survival of sympathetic neurons.

Pub. Date : 2005 Feb 1

PMID : 15361069






1 Functional Relationships(s)
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1 Inhibition of PP activity by phosphatidic acid (which has been reported to be a selective inhibitor of PP-1c) and tautomycin (a PP-1 and PP-2A inhibitor), but not by 10 nM okadaic acid, abolished the anti-apoptotic effect of ceramide in NGF-deprived neurons, suggesting that activation of PP-1c is required for ceramide-induced neuronal survival. tautomycin protein phosphatase 1 catalytic subunit gamma Homo sapiens