Title : Complement activation by cellulose: investigation of the effects of time, area, flow rate, shear rate and temperature on C3a generation in vitro, using a parallel plate flow cell.

Pub. Date : 1998 Jul

PMID : 15348869






3 Functional Relationships(s)
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1 The flow cell is used to conduct an investigation into the in vitro generation of C3a by a regenerated cellulose membrane, Cuprophan. cuprammonium cellulose complement C3 Homo sapiens
2 The effects of experimental variables such as temperature, blood flow rate, contact area and wall shear rate on C3a generation by Cuprophan were studied. cuprammonium cellulose complement C3 Homo sapiens
3 The results show that C3a generation by Cuprophan is lower at 12 degrees C than at 22 degrees C, which is in turn lower than C3a generation at 37 degrees C. Furthermore, a decrease in contact area, and increase in wall shear rate and blood flow rate, can produce a decrease in C3a concentration. cuprammonium cellulose complement C3 Homo sapiens