Title : Effect of various catechins on the IL-12p40 production by murine peritoneal macrophages and a macrophage cell line, J774.1.

Pub. Date : 2004 Sep

PMID : 15340218






1 Functional Relationships(s)
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1 These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation. Gallic acid mitogen-activated protein kinase 14 Mus musculus