Pub. Date : 2004 Sep
PMID : 15340218
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | EGCG inhibited LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), but not Jun N-terminal kinase (JNK), while EGCG augmented LPS-induced phosphorylation of p44/p42 extracellular signal-related kinase (ERK). | epigallocatechin gallate | mitogen-activated protein kinase 3 | Mus musculus |
2 | EGCG inhibited LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), but not Jun N-terminal kinase (JNK), while EGCG augmented LPS-induced phosphorylation of p44/p42 extracellular signal-related kinase (ERK). | epigallocatechin gallate | mitogen-activated protein kinase 3 | Mus musculus |
3 | EGCG inhibited LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), but not Jun N-terminal kinase (JNK), while EGCG augmented LPS-induced phosphorylation of p44/p42 extracellular signal-related kinase (ERK). | epigallocatechin gallate | mitogen-activated protein kinase 3 | Mus musculus |
4 | EGCG inhibited LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), but not Jun N-terminal kinase (JNK), while EGCG augmented LPS-induced phosphorylation of p44/p42 extracellular signal-related kinase (ERK). | epigallocatechin gallate | mitogen-activated protein kinase 3 | Mus musculus |
5 | EGCG inhibited LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), but not Jun N-terminal kinase (JNK), while EGCG augmented LPS-induced phosphorylation of p44/p42 extracellular signal-related kinase (ERK). | epigallocatechin gallate | mitogen-activated protein kinase 3 | Mus musculus |
6 | These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation. | epigallocatechin gallate | mitogen-activated protein kinase 3 | Mus musculus |