Title : Protein surface-assisted enhancement in the binding affinity of an inhibitor for recombinant human carbonic anhydrase-II.

Pub. Date : 2004 Sep 8

PMID : 15339172






1 Functional Relationships(s)
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1 The steady-state kinetic and the ligand binding data revealed that the attachment of iminodiacetate (IDA)-Cu(2+) to benzenesulfonamide (via a triethylene glycol spacer) enhanced its binding affinity for hCA-II by about 40-fold. triethylene glycol carbonic anhydrase 2 Homo sapiens