Title : Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

Pub. Date : 2004 Sep 6

PMID : 15337792






1 Functional Relationships(s)
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1 Theophylline induced a sixfold increase in HDAC activity in COPD AM lysates and significantly enhanced dexamethasone suppression of induced IL-8 release, an effect that was blocked by the HDAC inhibitor trichostatin A. trichostatin A C-X-C motif chemokine ligand 8 Homo sapiens