Title : Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2: two mechanisms that cooperatively increase p53 function in colon cancer cells.

Pub. Date : 2004 Nov

PMID : 15337531






5 Functional Relationships(s)
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1 We show here that a decrease in Ras in SW480 cells induced either by the Ras inhibitor farnesylthiosalicylic acid (FTS) or by K-Ras antisense oligonucleotides, resulted in a similar increase in p53 protein. farnesylthiosalicylic acid tumor protein p53 Homo sapiens
2 We show here that a decrease in Ras in SW480 cells induced either by the Ras inhibitor farnesylthiosalicylic acid (FTS) or by K-Ras antisense oligonucleotides, resulted in a similar increase in p53 protein. farnesylthiosalicylic acid tumor protein p53 Homo sapiens
3 Consistent with the Ras/Raf/MEK/ERK-mediated control of Mdm2, treatment of SW480 cells with the Ras inhibitor FTS caused a marked (80%) decrease in Mdm2, which itself would account for the increase in p53. farnesylthiosalicylic acid tumor protein p53 Homo sapiens
4 However, FTS also caused a 1.6-fold increase in p53 mRNA, indicative of a Ras-dependent mechanism that regulates p53 transcription. farnesylthiosalicylic acid tumor protein p53 Homo sapiens
5 However, FTS also caused a 1.6-fold increase in p53 mRNA, indicative of a Ras-dependent mechanism that regulates p53 transcription. farnesylthiosalicylic acid tumor protein p53 Homo sapiens