Title : Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.

Pub. Date : 1992 Apr 17

PMID : 1533422






1 Functional Relationships(s)
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1 This model, which is described in detail, is consistent with observed affinities of potent NMDA antagonists and has provided an explanation for the observed periodicity in affinities for the known antagonists AP5, AP6, and AP7. N-Methylaspartate adaptor related protein complex 5 subunit beta 1 Homo sapiens