Pub. Date : 2004 Sep
PMID : 15328100
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In contrast, ribavirin at physiological doses had no effect on DC maturation but markedly suppressed the production of TNF-alpha, IL-10, and IL-12(p70). | Ribavirin | tumor necrosis factor | Homo sapiens |
| 2 | The suppression of IL-12(p70) and TNF-alpha in maturing DCs may explain the reduction in hepatic inflammation observed during ribavirin monotherapy. | Ribavirin | tumor necrosis factor | Homo sapiens |
| 3 | Combination alpha interferon-ribavirin therapy may alter the cytokine profile of maturing DCs overall by suppressing IL-10 production but maintaining IL-12(p70) and TNF-alpha production, a pattern that would favor viral elimination through downstream effects on T cells. | Ribavirin | tumor necrosis factor | Homo sapiens |