Title : 2,3,7,8-Tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation.

Pub. Date : 2004 Sep

PMID : 15322241






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 p21(WAF1/CIP1), which is involved in the assembly of cyclin D1/cyclin-dependent kinase-4 complexes, was increased by DHT or TCDD when each compound was administered singly but was reduced to background levels in cells simultaneously treated with DHT and TCDD. Dihydrotestosterone cyclin D1 Homo sapiens