Title : Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase.

Pub. Date : 2004 Oct 29

PMID : 15322091






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Nox1 and Nox4, homologues of the leukocyte NADPH oxidase subunit Nox2 (gp91phox) mediate superoxide anion formation in various cell types. Superoxides NADPH oxidase 1 Homo sapiens
2 We provide evidence that p22phox directly interacts with Nox1 and Nox4, to form an superoxide-generating NADPH oxidase and demonstrate that mutation of the potential heme binding site in the Nox proteins disrupts the complex formation of Nox1 and Nox4 with p22phox. Superoxides NADPH oxidase 1 Homo sapiens