Title : Evidence for inhibition mediated by coassembly of GABAA and GABAC receptor subunits in native central neurons.

Pub. Date : 2004 Aug 18

PMID : 15317850






1 Functional Relationships(s)
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1 Application of the GABA(C) receptor agonist cis-4-aminocrotonic acid (100-800 microM) requires the rho1 subunit to elicit responses, which surprisingly are blocked independently by antagonists to GABA(A) (bicuculline, 10 microM) and GABA(C) [(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA); 40-160 microM] receptors. Bicuculline gamma-aminobutyric acid type A receptor subunit rho3 Homo sapiens