Title : Enhancing effect of dietary cholesterol and inhibitory effect of pravastatin on allergic pulmonary inflammation.

Pub. Date : 2004 Sep-Oct

PMID : 15316134






3 Functional Relationships(s)
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1 Following sensitization and inhalation exposure to ovalbumin, the bronchoalveolar lavage fluid of mice in the cholesterol group contained higher numbers of eosinophils and elevated levels of IL-5, PGE(2), and MCP-1. Cholesterol serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus
2 Although dietary cholesterol did not alter baseline IL-12 in the lungs, in mice challenged with ovalbumin the IL-12 levels were reduced in the cholesterol group and elevated significantly in the pravastatin group. Cholesterol serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus
3 Although dietary cholesterol did not alter baseline IL-12 in the lungs, in mice challenged with ovalbumin the IL-12 levels were reduced in the cholesterol group and elevated significantly in the pravastatin group. Cholesterol serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus